There are many organizations working on vaccines, small molecules and antibody treatments for nCOV SAR-2, but there remains a need for the development of a rapid-response treatments that can be deployed against SARS-2 and other future viral outbreaks when effective vaccines and antibodies are undetermined. While vaccination is a well-established tool for immunity-based protection, a lack of a safe first-response treatment has lead to the most expensive event in U.S. history, and nearly the most costly in terms of lives lost…while awaiting a vaccine.
Halo-Bio is pivoting our patented technologies towards the development of a rapid-response treatment targeting intercellular coronavirus infections as a tool to prevent significant loss of life and the threat of economic security. If this medical treatment were available today, those with severe viral infections could have been treated and those without severe responses could have contributed towards herd immunity while maintaining a normal life.
We are investigating a hypothesis identifying a potential achilles heal which leads coronavirus self-destruction using our RNA technology. This method holds the potential to be a “universal treatment” towards neutralizing infections without the use of potentially harmful small molecules and especially useful in combination with, or prior to, effective antibody or vaccine deployment. This nano biotechnology is scalable and can be formulated for a number of delivery modalities best suited for reaching infected tissue.
This project was started in January and finished computational designs in early February. The original designs using the genome sequences provided by researchers in Wuhan, China continue to be updated with alignments toward mutated strains of nCOV SARS-2. We are preparing candidate MV-RNA RNAi triggers and CORE RNA nanostructure genes for production and testing. With a lead-candidate in-hand, we look forward to collaboratively preparing this material for additional validation and peer review.
When completed, this biological nanoparticle will provide a novel treatment for early-stage infections of the lower respiratory tract to prevent both the severe injury before the dissemination of the virus to other organs. It is our expectation that intracellular expression of fusogenic viral spike protein of coronavirus leads to membrane dysfunction and irreversible damage during viral replication in lung epithelium. To prevent membrane damage, and viral shedding, intercellular viral expression must be shut down. As such, our endpoint goal is to significantly reduce or eliminate viral expression and replication within infected cells while having no effect on healthy ones.
We invite any researchers with appropriate experience and capabilities to join us in this endeavor.
Stay safe and be well,
Todd M. Hauser, Founder